One patient taking high levels of biotin died following falsely low troponin test results when a troponin test known to have biotin interference was used. Specifically, biotin lab interference has caused falsely low troponin results, which may lead to missed diagnosis and potentially serious clinical implications. Adverse events, including one death, related to biotin interference with lab tests have been reported. Radiolabeled biotin is used for pretargeted radioimmunotherapy of cancerous tumors.īiotin in blood or other samples taken from patients who are ingesting higher biotin dosages (i.e., doses of 10 to 300 mg biotin/day) in dietary supplements, including multivitamins, prenatal vitamins, and supplements for hair, skin, and nail growth, can cause clinically significant incorrect lab test results (falsely high or falsely low results) in assays that use biotin-streptavidin technology. Biotin is found in many cosmetics products. It has also been used in pregnancy, hemodialysis, and peritoneal dialysis, as biotin deficiency is more likely in these situations. As a dietary supplement, biotin has been promoted to be useful in the treatment of hair and nail problems, cradle cap (seborrheic dermatitis) in phenylketonuria patients, biotinidase deficiency, diabetes, peripheral neuropathy, candida infections, and high cholesterol. Sources of biotin include organ meats, eggs, fish, seeds, and nuts. Mammals must consume biotin to replenish stores. Biotin functions as an essential cofactor for five carboxylases that catalyze steps in fatty acid, glucose, and amino acid metabolism. Biotin is also an important factor in histone modifications, gene regulation, and cell signaling. It is found primarily in liver, kidney, and muscle. Biotin (vitamin H coenzyme R classified as a B vitamin) is a dietary component that is important for the metabolism of carbohydrates, fats, and amino acids.
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